Solubilities of Cimaterol and Mabuterol in SF-CO2


The solubilities of two -agonists, cimaterol and mabuterol, insupercritical carbon dioxide (SF-CO2) were measured by arecirculating method at temperatures of 40 C and 60 C
andpressures between 9 MPa to 49 MPa. The compounds exhibit very limitedsolubilities in the range of 10-5 to 10-7 (mole fraction).Cimaterol has a higher solubility than that of
mabuterol. Theexperimental data of solubility were correlated by four density-basedmodels. The correlation accuracy highly depends on the systeminvestigated, which is mainly
determined by the density ranges andtemperature. wisepoqder Mabuterol powder
The solubilities of two -agonists, cimaterol and mabuterol, insupercritical carbon dioxide (SF-CO2) were measured by arecirculating method at temperatures of 40 C and 60 C
andpressures between 9 MPa to 49 MPa. The compounds exhibit very limitedsolubilities in the range of 10-5 to 10-7 (mole fraction).Cimaterol has a higher solubility than that of
mabuterol. Theexperimental data of solubility were correlated by four density-basedmodels. The correlation accuracy highly depends on the systeminvestigated, which is mainly determined by the density ranges andtemperature.




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